Ukusetshenziswa kwe-Ordinary Zinc Oxid ku-Anti-diarrhea of Piglets

III. Izinselelo zohudo kumaphuphu alunyuliwe kanye nenani lomtholampilo lokui-zinc oxide

Ukulunyulwa kwengulube kuyisenzakalo esikhulu esicindezelayo empilweni yengulube. Izinkinga ezinjengokungasebenzi kahle kwesithiyo samathumbu, ukungakhiqizi ngokwanele kwama-enzyme okugaya ukudla, nokungalingani kwezitshalo kuvame ukuholela esihudo sangemva kokulunyulwa (PWD), esibeka engcupheni ukukhula kanye nezinzuzo zokuzalanisa kwamachwane. Kusukela ezejwayelekilei-zinc oxidekwatholakala ukuthi kunemiphumela ebalulekile yokulwa nesifo sohudo ngeminyaka yawo-1980, sekube “izinga legolide” lemboni yemfuyo yomhlaba wonke ukubhekana ne-PWD. Ucwaningo luye lwabonisa ukuthi ukwengeza 2500-3000 mg/kgi-zinc oxideinganciphisa izinga lohudo ngo-40% -60%, kuyilapho ikhulisa ukuzuza kwesisindo sansuku zonke ngo-10% -15%. Inani layo eliyinhloko lilele ekuzinziseni ngokushesha indawo yamathumbu ngokusebenzisa izindlela eziningi, okuhlinzeka ngokuvikeleka okubalulekile kwesikhashana kumantshontsho engulube.

IV.Indlela yokusebenza yei-zinc oxidengokumelene nesifo sohudo

1)Ukuqinisa umgoqo womzimba wamathumbu

I-Zinc oxideivuselela ukwanda kwamangqamuzana e-epithelial emathunjini, ikhulise kakhulu isilinganiso sobude be-villus yamathumbu ekujuleni kwe-crypt, ithuthukise indawo engaphezulu ukuze imunce izakhi, futhi ngesikhathi esifanayo ilawula ukubonakaliswa kwamaprotheni ahlangene (i-Occludin, i-ZO-1), inciphisa ukungena kwe-mucosal yamathumbu emathunjini, futhi ivimbele i-pathogen. Ivikela umsebenzi wokuvimbela ulwelwesi lwamathumbu emathunjini, ithuthukise ikhono le-antibacterial lamachwane, futhi inciphise nesifo sohudo.

Umdwebo 2Imiphumela yemithamo ehlukene yei-zinc oxideku-morphology yamathumbu ezingulube

Umdwebo 3Imiphumela yemithamo ehlukene yei-zinc oxidekuma-protein ahlanganayo emathunjini kumachwane

2)Ukulawula ibhalansi ye-microbial yamathumbu

I-Zinc oxideikhiqiza ama-radicals mahhala e-hydrogen peroxide emathunjini, okuyisici esibalulekile ekusebenzeni kwe-antibacteriali-zinc oxide. Umthamo omkhului-zinc oxideivimbela ngokuqondile ukwanda kwamabhaktheriya e-pathogenic afana ne-Escherichia coli ne-Salmonella ngokukhulula izinhlobo ze-oxygen esebenzayo (ROS), kuyilapho ikhuthaza ukoloni lwamabhaktheriya anenzuzo njengeLactobacillus.

Umdwebo 4Imiphumela yezokudlai-zinc oxidekuma-microorganisms e-cecal kuma-piglets

3) I-zinc ephezulu ikhuthaza ukukhula kwezingulube

Ingcindezi yokulumula idala ukwehla okungama-30% kokugayeka kokudla ukudla, kanye nokugayeka kokudla okunomsoco ezingulubeni ezilunyuliwe kuyehla nakakhulu uma zisesimweni sohudo. Ucwaningo luye lwabonisalokhoukwengeza imithamo ephezulu yei-zinc oxideekudleni kungakhuphula izinga le-zinc egazini, iphinde ilawule ukukhiqizwa kwama-peptide obuchopho nama-hormone endlala, futhikhuthaza amazinyane engulube ukuba adle. Ngesikhathi esifanayo, ukwanda kokuqukethwe kwe-zinc egazinikungabaukukhuthaza ngempumelelo ukuhlanganiswa nokusebenza kwama-enzyme wokugaya ukudla, ngcono ukugayeka kokudla kwezakhi, futhiukwandisa ukuzuza kwesisindo sansuku zonke samachwane.

Umdwebo 5Imithelela ye-zinc oxide ekusebenzeni kokukhula kwamachwane alunyuliwe

IV. Uhlelo Lokusebenza Lwesayensi Nezinyathelo Zokuqapha

1. Umthamo onembile kanye nomjikelezo wokusetshenziswa

Nakuba kushiwo ukuthi i-zinc ephezulu (1600-2500 mg/kgi-zinc oxide) okuphakelayo kungasetshenziswa kuphela ku-”emasontweni amabili okuqala ngemva kokulunyulwa”, amapulazi amaningi ezingulube anweba ukusetshenziswa kokudla okuphezulu kwe-zinc amasonto angu-2-8. Ngalesi sikhathi, amanye amapulazi ezingulube azothola”high zinc side effects”, ezibonakala njengezinwele eziwugqinsi nezinde kanye nesikhumba esifiphele.

2. Khethai-zinc oxidengokuzinza okuphezulu ukuthuthukisa umphumela womkhiqizo

I-bioavailability ye-i-zinc oxideekhiqizwa inqubo emanzi iphakeme kakhulu kunaleyo yei-zinc oxideekhiqizwa inqubo eqondile. Ngakho-ke, lapho ukhethai-zinc oxideimikhiqizo, inqubo yokukhiqiza yayo kufanele futhi icatshangelwe.

5. Amathrendi embonini kanye ne-Alternative Technology Outlook

Nakuba i-EU ilinganisele inani le-zinc elingezwe ku-150 mg/kg, umkhuba wasekhaya ubonisa ukuthi ukususa ngokuphelele i-zinc ephezulu kusabhekene nezingqinamba zobuchwepheshe. Ezinye izindlela zamanje ezifana ne-nanoi-zinc oxide(300 mg/kg) kanye ne-basic zinc chloride (1200 mg/kg) kunganciphisa umthamo, kodwa izindleko zabo ziphezulu, ukuzinza kwenqubo akwanele, futhi ukuphepha kwesikhathi eside kusadinga ukuqinisekiswa. Ngakho-ke,ezejwayelekilei-zinc oxidekuseyisinqumo esingcono kakhulu samapulazi amancane naphakathi nendawo ukulinganisa izindleko kanye nomphumela.

Okuvamilei-zinc oxide

Isizukulwane sokuqala seSustari-zinc oxide

Ukuhlanzeka okuphezulu + okuqukethwe okuphezulu + izindleko eziphansi = izinzuzo ezintathu kokukodwa

Othintana naye Abezindaba:
Elaine Xu
I-SUSTAR
Email: elaine@sustarfeed.com
Iselula/WhatsApp: +86 18880477902