Izindaba - Ukusetshenziswa kwe-Zinc Oxid Ejwayelekile Ekulweni Nohudo Lwamachwane Amancane

Mina.

I-zinc oxide, eyaziwa kakhulu ngokuthi i-zinc white, iyi-amphoterici-zinc oxideengancibiliki emanzini kodwa encibilika ku-asidi kanye ne-alkali eqinile. Ifomula yayo yamakhemikhali yi-ZnO, isisindo sama-molecule singama-81.37, inombolo ye-CAS ingu-1314-13-2, iphuzu lokuncibilika lingu-1975℃ (ukubola), iphuzu lokubila lingu-2360℃, futhi ayincibiliki emanzini. Isetshenziswa kabanzi emikhakheni engaphezu kuka-20 efana nepulasitiki, imikhiqizo ye-silicate, irabha yokwenziwa, izinto zokugcoba, upende kanye nezinto zokumboza, amafutha okugcoba, izinti, ukudla, amabhethri, izinto ezivimbela ilangabi,njll.

Umfanekiso 1I-zinc oxideisampula

III. Izinselele zohudo ezingulubeni ezincane ezilunyuliwe kanye nenani lezokwelaphai-zinc oxide

Ukuyekisa ukulunyulwa kuyisenzakalo esicindezelayo empilweni yengulube encane. Izinkinga ezifana nokusebenza okubuthakathaka kokuvimbela amathumbu, ukukhiqizwa okunganele kwama-enzyme okugaya ukudla, kanye nokungalingani kwezitshalo kuvame ukuholela ekuhudweni ngemva kokuyekisa ukulunyulwa (i-PWD), okusongela kakhulu ukusebenza kokukhula kanye nezinzuzo zokuzalana kwezingulube ezincane.i-zinc oxideKwatholakala ukuthi kunemiphumela ebalulekile yokulwa nesifo sohudo ngawo-1980, sekuyinto “ejwayelekile” embonini yezilwane emhlabeni wonke ukubhekana nabantu abakhubazekile. Izifundo zikhombisile ukuthi ukwengeza u-2500-3000 mg/kgi-zinc oxidekunganciphisa izinga lohudo ngo-40%-60%, kuyilapho kwandisa ukukhuluphala kwansuku zonke ngo-10%-15%. Inani layo eliyinhloko lisekuzinziseni ngokushesha indawo yamathumbu ngokusebenzisa izindlela eziningi, okuhlinzeka ngokuvikelwa okubalulekile kwesikhashana kwamachwane ezingulube.

Izinselele zohudo ezingulubeni ezincelisiwe kanye nenani le-zinc oxide emtholampilo

IV.Indlela yokusebenza kwe-i-zinc oxidengokumelene nesifo sohudo

1)Ukuqinisa isithiyo somzimba samathumbu

I-zinc oxideKuvuselela ukwanda kwamaseli e-epithelial emathunjini, kwandisa kakhulu isilinganiso sokuphakama kwe-intestinal villus kuya ekujuleni kwe-crypt, kuthuthukisa indawo engaphezulu yokumuncwa kwezakhamzimba, futhi ngasikhathi sinye kukhulisa ukubonakaliswa kwamaprotheni e-tight junction (Occludin, ZO-1), kunciphisa ukungena kwe-mucosal emathunjini, futhi kuvimbele ukuhlasela kwamagciwane. Kuvikela umsebenzi wokuvimbela i-mucosal emathunjini, kuthuthukisa ikhono lokulwa namagciwane lamachwane ezingulube, futhi kunciphisa isifo sohudo.

Umfanekiso 2Imiphumela yemithamo ehlukene yei-zinc oxidemayelana nokwakheka kwamathumbu ezingulube ezincane

Isibalo 3 Imiphumela yemithamo ehlukene ye-zinc oxide kumaprotheni e-intestinal tight junction kuma-piglens

Umfanekiso 3Imiphumela yemithamo ehlukene yei-zinc oxidekumaprotheni okuhlangana kwamathumbu amancane ezingulubeni ezincane

2)Ukulawula ibhalansi yamagciwane emathunjini

I-zinc oxideikhiqiza ama-free radical e-hydrogen peroxide emathunjini, okuyisici esibalulekile emsebenzini wokulwa namagciwanei-zinc oxideUmthamo ophezului-zinc oxideivimbela ngqo ukwanda kwamagciwane abangela izifo njenge-Escherichia coli kanye ne-Salmonella ngokukhulula izinhlobo ze-oxygen ezisebenzayo (i-ROS), kuyilapho ikhuthaza ukwakheka kwamagciwane anenzuzo njenge-Lactobacillus.

Umfanekiso 4Imiphumela yokudlai-zinc oxidekuma-microorganisms ase-cecal ezingulubeni ezincane

3) I-zinc ephezulu ikhuthaza ukukhula kwamachwane ezingulube

Ukucindezeleka kokulunyulwa kubangela ukwehla okungu-30% kokugayeka kokudla, futhi ukugayeka kwezakhamzimba ezingulubeni ezincelisiwe kuncipha kakhulu uma zisesimweni sohudo. Izifundo zikhombisilelokhoukwengeza imithamo ephezulu yei-zinc oxideukudla kungakhuphula izinga le-zinc egazini, ukulawula ngokwengeziwe ukukhiqizwa kwama-peptides e-brain gut kanye nama-hormone endlala, futhikhuthaza amaphuphu ukuba adle. Ngesikhathi esifanayo, ukwanda kokuqukethwe kwe-zinc egaziniithiniukukhuthaza ngempumelelo ukwakheka kanye nokusebenza kwama-enzyme okugaya ukudla, kuthuthukisa ukugayeka kwezakhamzimba, futhikwandisa ukukhuluphala kwansuku zonke kwamachwane ezingulube.

Umfanekiso 5Imiphumela ye-zinc oxide ekusebenzeni kahle kokukhula kwezingulube ezincane ezilunyuliwe

IV. Uhlelo Lokusebenza Lwesayensi kanye Nezinyathelo Zokuqapha

1. Isilinganiso esinembile kanye nomjikelezo wokusetshenziswa

Nakuba kunqunywe ukuthi i-zinc ephezulu (1600-2500 mg/kg)i-zinc oxide) ukudla kungasetshenziswa kuphela ku-"amasonto amabili okuqala ngemva kokukhipha isisu", amapulazi amaningi ezingulube andisa ukusetshenziswa kokudla okune-zinc eningi amasonto ama-2-8. Ngalesi sikhathi, amanye amapulazi ezingulube azobhekana nakho"imiphumela emibi ephezulu ye-zinc", okuvame ukubonakala njengezinwele ezinde nezijiyile kanye nesikhumba esibuthakathaka.

2. Khethai-zinc oxidengokuqina okuphezulu ukuthuthukisa umphumela womkhiqizo

Ukutholakala kwezinto eziphilayoi-zinc oxideokukhiqizwa yinqubo emanzi kuphakeme kakhulu kune-i-zinc oxideokukhiqizwa yinqubo eqondile. Ngakho-ke, uma ukhethai-zinc oxideimikhiqizo, inqubo yayo yokukhiqiza nayo kufanele icatshangelwe.

5. Izitayela Zemboni kanye Nombono Wezobuchwepheshe Obuhlukile

Nakuba i-EU inciphise inani le-zinc elingeziwe ku-150 mg/kg, umkhuba wasekhaya ukhombisa ukuthi ukufaka esikhundleni ngokuphelele i-zinc ephezulu kusabhekene nezingqinamba zobuchwepheshe. Ezinye izindlela zamanje ezifana ne-nanoi-zinc oxide(300 mg/kg) kanye ne-zinc chloride eyisisekelo (1200 mg/kg) kunganciphisa umthamo, kodwa izindleko zazo ziphezulu, ukuzinza kwenqubo akwanele, futhi ukuphepha kwesikhathi eside kusadingeka kuqinisekiswe. Ngakho-ke,okuvamilei-zinc oxidekuseyisinqumo esingcono kakhulu samapulazi amancane naphakathi ukuze kulinganiswe izindleko nemiphumela.